Which of the following drugs is a selective alpha-2 antagonist that has been historically used for the treatment of erectile dysfunction but is rarely used now due to cardiovascular side effects?
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Correct answer: Yohimbine
Yohimbine increases central sympathetic outflow by blocking presynaptic alpha-2 receptors. This inhibition prevents the normal negative feedback loop of norepinephrine, leading to increased heart rate and blood pressure.
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