Which beta-blocker is primarily eliminated by the kidneys and has very low lipid solubility, leading to fewer CNS side effects?
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Correct answer: Atenolol
Atenolol is hydrophilic (water-soluble) and is excreted largely unchanged in the urine. Because it does not cross the blood-brain barrier effectively, it is often preferred for patients who experience nightmares or depression on lipophilic beta-blockers.
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