Which beta-blocker is highly lipophilic and readily crosses the blood-brain barrier, making it more likely to cause CNS side effects like vivid dreams and depression?
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Correct answer: Propranolol
Propranolol is the most lipophilic of the common beta-blockers. While this allows it to be used for migraine prophylaxis, it also increases its accumulation in the brain, leading to higher rates of neurological side effects.
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