Macrolides · Pharmacology

What is the primary route of elimination for Azithromycin?

  1. Renal excretion as unchanged drug
  2. Hepatic metabolism via CYP2C19
  3. Biliary excretion and fecal elimination
  4. Glomerular filtration without tubular secretion
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Correct answer: Biliary excretion and fecal elimination

Azithromycin is primarily eliminated unchanged through the bile into the feces. Less than 10% of the drug is excreted in the urine, so dose adjustment is generally not required for mild to moderate renal impairment.

Difficulty: Medium Question 15 of 20

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