Which drug is often used as a substitute for Rifampin in HIV patients receiving protease inhibitors because it is a less potent inducer of CYP450?
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Correct answer: Rifabutin
Rifabutin has antitubercular activity comparable to rifampin but is a much weaker inducer of CYP3A4. That makes it far easier to combine with protease inhibitors and other antiretrovirals in patients coinfected with HIV.
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