A patient develops 'Flu-like syndrome' (fever, chills, myalgia) when taking Rifampin. This is most likely to occur under which dosing schedule?
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Correct answer: Intermittent high-dose therapy
The immunological flu-like syndrome caused by rifampin is far more common when the drug is given intermittently at high doses, for example twice-weekly regimens, than with standard daily dosing. Antibodies formed between doses are thought to drive the reaction.
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