Which antitubercular drug is structurally related to Isoniazid and also inhibits mycolic acid synthesis, but causes significant GI irritation and a metallic taste?
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Correct answer: Ethionamide
Ethionamide is a second-line drug that inhibits mycolic acid synthesis via a pathway similar to INH. It is often poorly tolerated due to intense gastric irritation and various neurological side effects.
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