Aminoglycosides · Pharmacology

A patient on Gentamicin develops a high-pitched tinnitus and vertigo. Which part of the ear is likely damaged?

  1. Middle ear ossicles (malleus, incus, stapes)
  2. Cochlear and vestibular hair cells
  3. Tympanic membrane
  4. Eustachian tube
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Correct answer: Cochlear and vestibular hair cells

Aminoglycosides are directly toxic to the sensory hair cells within the cochlea (leading to hearing loss) and the vestibular apparatus (leading to balance issues and vertigo). This damage is often permanent.

Difficulty: Medium Question 14 of 20

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