What is the primary difference between Prednisone and Prednisolone?
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Correct answer: Prednisone is a prodrug that must be converted to Prednisolone in the liver
Prednisone is biologically inactive and must be converted to its active form, prednisolone, by the enzyme 11-beta-hydroxysteroid dehydrogenase in the liver. Patients with severe liver disease may require prednisolone directly.
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