Which of the following describes the primary mechanism of action of glucocorticoids at the cellular level?
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Correct answer: Binding to intracellular receptors to alter gene transcription
Glucocorticoids are lipophilic and cross the cell membrane to bind with cytosolic receptors. The drug-receptor complex then translocates to the nucleus, where it binds to glucocorticoid response elements (GREs) to upregulate or downregulate specific protein synthesis.
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