Which enzyme's activity is indirectly inhibited by corticosteroids through the induction of annexin A1 (lipocortin)?
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Correct answer: Phospholipase A2 (PLA2)
Corticosteroids stimulate the synthesis of annexin A1, which inhibits phospholipase A2. This prevents the release of arachidonic acid from membrane phospholipids, effectively cutting off the precursor for both prostaglandins and leukotrienes.
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