In the context of precision oncology, what is the significance of 'tumor mutational burden' (TMB) derived from NGS data?
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Correct answer: It predicts response to immunotherapy as a biomarker
Tumor Mutational Burden (TMB) is the total number of somatic mutations per megabase of DNA sequenced. A high TMB correlates with increased neoantigen production, which can make the tumor more visible to the immune system, thereby predicting a better response to immune checkpoint inhibitors.
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