Fungal Infections · Pathology

Which of the following laboratory tests detects a component of the cell wall of many fungi, excluding Mucorales and Cryptococcus?

  1. Serum galactomannan assay
  2. 1,3-beta-D-glucan test
  3. PCR for 16S rRNA
  4. Quellung reaction
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Correct answer: 1,3-beta-D-glucan test

The (1,3)-beta-D-glucan assay is a serum marker for invasive fungal infections. It is found in the cell walls of Candida, Aspergillus, and Pneumocystis, but notably absent in Mucorales and Cryptococcus.

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