A lung biopsy from a patient in the Ohio River Valley shows small, 2–4 micrometer intracellular yeasts within macrophages. This finding is most characteristic of:
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Correct answer: Histoplasmosis
Histoplasma capsulatum is a dimorphic fungus that exists as small yeasts within the phagosomes of macrophages. In the United States, it is endemic to the Ohio and Mississippi River Valleys.
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