Bacterial Infections · Pathology

What is the primary virulence factor of Bacillus anthracis that allows it to evade the host immune system?

  1. A lipopolysaccharide endotoxin
  2. A polypeptide capsule composed of D-glutamic acid
  3. Production of streptolysin O
  4. Inhibition of phagosome-lysosome fusion
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Correct answer: A polypeptide capsule composed of D-glutamic acid

Unlike most bacteria which have polysaccharide capsules, B. anthracis has a unique capsule made of poly-D-glutamic acid. This capsule is anti-phagocytic and essential for the bacterium to cause systemic disease.

Difficulty: Medium Question 8 of 20

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