Which of the following describes the mechanism of Goodpasture syndrome?
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Correct answer: Anti-GBM antibodies against alpha-3 chain of Type IV collagen
Goodpasture syndrome is a Type II hypersensitivity where autoantibodies target fixed antigens in the glomerular and alveolar basement membranes. Immunofluorescence shows a characteristic smooth, linear pattern of IgG deposition.
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