Fibrinoid necrosis in small blood vessels is a histological hallmark of which hypersensitivity reaction?
Show answer and explanation
Correct answer: Type III
Fibrinoid necrosis occurs in Type III hypersensitivity (vasculitis) when immune complexes and complement activation cause severe damage to the vessel wall. The leakage of plasma proteins, including fibrin, creates a bright pink, smudgy appearance on H&E stains.
Keep practicing
More Hypersensitivity Reactions questions
- Which cytokine is essential for the 'isotype switching' of B-cells to IgE in Type I hypersensitivity?
- The 'lumpy-bumpy' or granular pattern of immunofluorescence in Post-Streptococcal Glomerulonephritis indicates:
- Which of the following clinical scenarios involves a 'hapten' mechanism causing Type IV hypersensitivity?
- Myasthenia gravis involves antibodies that inhibit a receptor without causing cell lysis. Which receptor is targeted?
- Which of the following is the 'late-phase' effector cell most associated with chronic allergic inflammation?
- In Type III hypersensitivity, what is the primary cause of neutrophilic recruitment to the site of immune complex deposition?