Which specific antibody test is the most specific (though not most sensitive) for Pernicious Anemia?
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Correct answer: Anti-intrinsic factor antibody
While anti-parietal cell antibodies are more sensitive, they occur in many forms of gastritis. Anti-intrinsic factor antibodies are highly specific for Pernicious Anemia, as they directly block the binding of B12 to IF.
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More Megaloblastic Anemia questions
- Which of the following describes the 'pancytopenia' often seen in severe megaloblastic anemia?
- What is the 'Schilling test' historically used to evaluate?
- A vegan diet is most likely to lead to which of the following over a long period?
- Why is it critical to rule out Vitamin B12 deficiency before treating a macrocytic anemia with Folate alone?
- Tropical sprue causes megaloblastic anemia primarily by causing malabsorption of:
- Megaloblastic anemia is primarily characterized by a defect in which of the following cellular processes?