Iron Deficiency Anemia · Pathology

Which of the following is the most sensitive early laboratory indicator of depleted iron stores in a patient developing iron deficiency anemia?

  1. Decreased hemoglobin level
  2. Decreased serum ferritin level
  3. Increased iron-binding capacity
  4. Decreased mean corpuscular volume
Show answer and explanation

Correct answer: Decreased serum ferritin level

Serum ferritin levels reflect the total body iron stores in the liver and bone marrow. It is the first laboratory parameter to decrease during the 'pre-latent' stage of iron deficiency, well before any changes in red cell morphology or hemoglobin occur.

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