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Iron Deficiency Anemia · Pathology

How does the Total Iron Binding Capacity (TIBC) typically change in iron deficiency anemia, and why?

  1. It decreases because the liver stops producing transferrin
  2. It increases as the liver produces more transferrin to capture iron
  3. It stays the same because it only measures albumin-bound iron
  4. It decreases because iron is needed to stabilize the transferrin molecule
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Correct answer: It increases as the liver produces more transferrin to capture iron

TIBC is an indirect measure of the blood's transferrin level. In iron deficiency, the liver increases transferrin synthesis to maximize the capture of any available iron, leading to an elevated TIBC.

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