Iron Deficiency Anemia · Pathology

What happens to the Red Cell Distribution Width (RDW) in the early stages of iron deficiency anemia?

  1. It decreases as cells become more uniform
  2. It remains unchanged until the anemia is severe
  3. It increases as smaller cells begin to appear
  4. It becomes zero because erythropoiesis stops
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Correct answer: It increases as smaller cells begin to appear

RDW measures the variation in red blood cell size (anisocytosis). In early iron deficiency, the RDW increases because the marrow begins producing microcytic cells, creating a diverse population of cell sizes.

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