Anemia Classification · Pathology

Which finding on a peripheral smear would help classify an anemia as 'Hereditary Spherocytosis'?

  1. Large ovalocytes and Howell-Jolly bodies
  2. Small, dark red cells lacking central pallor
  3. Pencil-shaped cells
  4. Basophilic stippling
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Correct answer: Small, dark red cells lacking central pallor

Spherocytes are RBCs that have lost their biconcave shape due to defects in the red cell membrane proteins. They appear smaller and more densely stained without the normal area of central pallor.

Difficulty: Medium Question 9 of 20

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