A 55-year-old male suffers a myocardial infarction. Which metabolic change occurs first within the ischemic cardiomyocytes?
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Correct answer: Decreased intracellular pH
Ischemia leads to a shift from aerobic respiration to anaerobic glycolysis. This results in the accumulation of lactic acid and inorganic phosphates, which lowers the intracellular pH and can lead to chromatin clumping.
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