Cell Death: Necrosis · Pathology

Why does liquefactive necrosis occur in a myocardial infarction if it is complicated by a secondary bacterial infection?

  1. Because heart muscle always liquefies after 24 hours
  2. The bacteria attract neutrophils which release hydrolytic enzymes
  3. The bacteria directly convert ATP into water
  4. The bacteria prevent the denaturation of structural proteins
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Correct answer: The bacteria attract neutrophils which release hydrolytic enzymes

While an uncomplicated myocardial infarction leads to coagulative necrosis, a secondary bacterial infection (septic infarction) brings in neutrophils. These inflammatory cells release potent hydrolytic enzymes that digest the tissue, shifting the pattern toward liquefactive necrosis.

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