Cell Death: Necrosis · Pathology

Which of the following describes the mechanism of coagulative necrosis?

  1. Rapid enzymatic digestion of cells and tissues by lysosomal hydrolases
  2. Immune complex deposition in the walls of small arteries
  3. Activation of the programmed cell death caspase cascade
  4. Denaturation of proteins and enzymes, blocking proteolysis
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Correct answer: Denaturation of proteins and enzymes, blocking proteolysis

Coagulative necrosis occurs when injury denatures both structural proteins and enzymes. This lack of enzymatic activity prevents the immediate proteolysis of dead cells, allowing the tissue to maintain its firm texture and structural outline for several days.

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