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Cell Death: Necrosis · Pathology

In a clinical setting, how can necrosis be detected via a blood test?

  1. By measuring the levels of anti-apoptotic Bcl-2 proteins
  2. By detecting the leakage of tissue-specific intracellular enzymes
  3. By observing an increase in serum albumin levels
  4. By measuring the rate of ATP consumption
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Correct answer: By detecting the leakage of tissue-specific intracellular enzymes

Because necrosis involves the loss of membrane integrity, intracellular enzymes leak into the blood. Examples include Troponins and CK-MB for myocardial necrosis, or ALT and AST for hepatic necrosis.

Difficulty: Medium Question 17 of 20

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