Which medication class is the most common cause of peptic ulcers in patients who are H. pylori negative?
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Correct answer: Non-steroidal anti-inflammatory drugs (NSAIDs)
NSAIDs inhibit cyclooxygenase (COX), which reduces the synthesis of protective prostaglandins (PGE2 and PGI2). This impairs mucus secretion, bicarbonate production, and mucosal blood flow, leading to ulceration.
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More Peptic Ulcer Disease questions
- The presence of 'coffee-ground' emesis in a patient with a known peptic ulcer indicates which complication?
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- Which of the following is an absolute requirement for the diagnosis of a gastric ulcer as benign on biopsy?
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