Peptic Ulcer Disease · Pathology

Cushing ulcers, associated with increased intracranial pressure, primarily develop due to:

  1. Decreased mucosal blood flow from shock
  2. Vagal overstimulation and hyperacidity
  3. Direct toxic effects of steroids
  4. Bacterial translocation
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Correct answer: Vagal overstimulation and hyperacidity

Increased intracranial pressure stimulates the vagus nerve nuclei, leading to excessive secretion of gastric acid. This is distinct from Curling ulcers, which are related to systemic ischemia in burn patients.

Difficulty: Medium Question 14 of 20

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