Which of the following macroscopic features is most characteristic of Crohn disease compared to Ulcerative Colitis?
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Correct answer: Presence of 'skip lesions' with areas of normal-appearing mucosa
Crohn disease is characterized by skip lesions, which are sharply demarcated areas of involvement separated by normal segments of bowel. In contrast, Ulcerative Colitis involves a continuous, diffuse inflammatory process.
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