Which of the following describes the mechanism by which NSAIDs cause acute gastritis?
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Correct answer: Inhibition of cyclooxygenase (COX) and prostaglandin synthesis
Prostaglandins (specifically PGE2 and PGI2) are essential for protecting the gastric mucosa by stimulating mucus and bicarbonate secretion. NSAIDs inhibit COX enzymes, depleting these protective prostaglandins and making the mucosa susceptible to acid injury.
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