What is the primary risk factor for the development of gastric adenocarcinoma and MALT lymphoma in patients with chronic gastritis?
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Correct answer: H. pylori infection
H. pylori is classified as a Group 1 carcinogen. The chronic inflammation it causes leads to a sequence of atrophy, metaplasia, dysplasia, and eventually adenocarcinoma; it also drives the B-cell proliferation seen in MALT lymphoma.
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