Which of the following proteins is the primary autoantibody target in Pemphigus Vulgaris?
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Correct answer: Desmoglein 3
Pemphigus vulgaris is characterized by IgG autoantibodies against desmoglein 3 (and sometimes desmoglein 1). This disrupts the desmosomes, leading to suprabasal acantholysis and blistering.
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