Pemphigus foliaceus differs from Pemphigus vulgaris histologically because the acantholysis occurs at which level?
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Correct answer: Subcorneal or within the granular layer
In Pemphigus foliaceus, autoantibodies target Desmoglein 1 only. Since Desmoglein 1 is primarily expressed in the upper layers of the epidermis, the blisters form superficially, often just below the stratum corneum.
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More Bullous Diseases questions
- Which of the following best describes 'acantholysis'?
- In the Salt-Split Skin technique, the autoantibodies in Bullous Pemphigoid bind to which side of the split?
- What is the primary histological finding in Bullous Impetigo?
- Which molecule is the target of autoantibodies in Cicatricial (Mucous Membrane) Pemphigoid?
- Direct immunofluorescence of Dermatitis Herpetiformis typically shows which pattern?
- Which bullous disease is characterized by 'festooning' of the dermal papillae into the blister cavity?