In Epidermolysis Bullosa Acquisita (EBA), the autoantibodies are directed against:
Show answer and explanation
Correct answer: Type VII Collagen
EBA is an acquired subepidermal bullous disease where IgG targets Type VII collagen, the main component of anchoring fibrils. This leads to deep blistering and scarring.
Keep practicing
More Bullous Diseases questions
- What is the classic histological description of the acantholysis in Hailey-Hailey disease?
- Which of the following proteins is the primary autoantibody target in Pemphigus Vulgaris?
- A skin biopsy shows a subepidermal blister with a dense infiltrate of eosinophils. Direct immunofluorescence (DIF) reveals linear IgG and C…
- Which histological feature is referred to as the 'tombstone' appearance in Pemphigus Vulgaris?
- Dermatitis herpetiformis is pathologically characterized by the presence of which of the following?
- Which bullous disease is characterized by a 'fishnet' or 'chicken-wire' pattern on direct immunofluorescence?