Fine Needle Aspiration Cytology · Pathology

A liver FNA shows cells with large nuclei, prominent nucleoli, and bile pigment in the cytoplasm. This most likely represents:

  1. Metastatic colon cancer
  2. Hepatocellular carcinoma
  3. Biliary cystadenoma
  4. Metastatic melanoma
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Correct answer: Hepatocellular carcinoma

The presence of bile in the cytoplasm of atypical cells is a strong diagnostic clue for Hepatocellular Carcinoma (HCC). Other features include trabecular growth patterns and endothelial wrapping.

Difficulty: Medium Question 16 of 20

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