Myocardial Infarction · Pathology

Which of the following is the most common cause of acute myocardial infarction?

  1. Coronary artery vasospasm
  2. Embolization from atrial fibrillation
  3. Atherosclerotic plaque disruption with thrombosis
  4. Autoimmune vasculitis of the epicardial coronary vessels
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Correct answer: Atherosclerotic plaque disruption with thrombosis

Most myocardial infarctions are caused by the acute disruption of an atheromatous plaque, which leads to the exposure of subendothelial collagen and the formation of an occlusive thrombus. This suddenly halts blood flow to the distal myocardium.

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