Hormone Replacement Therapy · NCLEX Exam

Why is progestogen included in combined estrogen and progestogen therapy for a post-menopausal woman with an intact uterus?

  1. Reduce hot flashes more effectively than estrogen given alone
  2. Protect the endometrium from hyperplasia
  3. Enhance bone mineral density beyond estrogen-only therapy
  4. Increase the long-term risk of invasive breast cancer
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Correct answer: Protect the endometrium from hyperplasia

When a woman with an intact uterus receives estrogen replacement, adding progestogen protects the endometrium from hyperplasia and possible malignancy.

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