Hormone Replacement Therapy · NCLEX Exam

Which route of estrogen administration is preferred for a woman with increased risk of venous thromboembolism?

  1. Oral estrogen
  2. Transdermal (patch/gel) estrogen
  3. Intramuscular estrogen injection
  4. Vaginal estrogen only
Show answer and explanation

Correct answer: Transdermal (patch/gel) estrogen

Transdermal estrogen bypasses first-pass liver metabolism and may carry lower risk of VTE compared to oral administration.

Difficulty: Medium Question 5 of 18

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