Immunotherapy and Targeted Therapy · NCLEX Exam

Targeted therapy may fail over time due to:

  1. Increased stability of the target protein over time
  2. The cancer carrying no driver mutations at all
  3. Resistance via secondary mutations or alternative signalling pathways
  4. Rapid and complete cure in most treated patients
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Correct answer: Resistance via secondary mutations or alternative signalling pathways

One limitation of targeted therapy is that cancer cells may develop resistance by activating alternative pathways or mutating the target, reducing long-term efficacy.

Difficulty: Medium Question 18 of 20

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