Chemotherapy Agents and Side Effects · NCLEX Exam

Leucovorin is often administered with methotrexate to:

  1. Enhance its cytotoxic effects
  2. Prevent folate-related toxicity
  3. Reduce its renal toxicity
  4. Stimulate immune function
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Correct answer: Prevent folate-related toxicity

Leucovorin rescues normal cells from methotrexate toxicity by replenishing folate stores, preventing severe side effects.

Difficulty: Medium Question 6 of 20

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