Chemotherapy Agents and Side Effects · NCLEX Exam

A patient receiving cyclophosphamide should be encouraged to increase fluid intake primarily to prevent:

  1. Severe constipation
  2. Hemorrhagic cystitis
  3. Marked myelosuppression
  4. Reversible alopecia
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Correct answer: Hemorrhagic cystitis

Cyclophosphamide can cause hemorrhagic cystitis due to acrolein accumulation in the bladder; hydration helps prevent this.

Difficulty: Medium Question 2 of 20

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