Gastric Glands · Histology

What is the primary secretory product of the Chief cells?

  1. Hydrochloric acid
  2. Intrinsic factor
  3. Gastrin
  4. Pepsinogen
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Correct answer: Pepsinogen

Chief cells synthesize and store pepsinogen in apical zymogen granules. Once secreted into the acidic environment of the stomach lumen, pepsinogen is converted into the active proteolytic enzyme, pepsin.

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