Vitamin C deficiency (scurvy) affects osteoblast function primarily by:
Show answer and explanation
Correct answer: Inhibiting proline hydroxylation in collagen
Vitamin C is a required cofactor for the enzymes that hydroxylate amino acids in procollagen. Without it, osteoblasts produce defective collagen that cannot form stable triple helices, leading to impaired bone formation.
Keep practicing
More Osteoblasts questions
- How do osteoblasts communicate with each other and with underlying osteocytes?
- Osteoblasts are typically found in which locations?
- Which transcription factor is considered the 'master regulator' of osteoblast differentiation?
- During intramembranous ossification, osteoblasts cluster together to form:
- Which vitamin is essential for the synthesis of osteocalcin by osteoblasts?
- What is the primary effect of intermittent low doses of Parathyroid Hormone (PTH) on osteoblasts?