Erythroblastosis Fetalis (Hemolytic Disease of the Newborn) is primarily caused by:
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Correct answer: Rh incompatibility between mother and fetus
When an Rh-negative mother carries an Rh-positive fetus, maternal IgG antibodies against the Rh (D) antigen cross the placenta and attack fetal erythrocytes. This leads to severe hemolysis, anemia, and the compensatory release of immature nucleated red blood cells (erythroblasts) into fetal circulation.
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