Which of the following describes the characteristic shape of erythrocytes in Sickle Cell Anemia under deoxygenated conditions?
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Correct answer: Crescent-shaped
In Sickle Cell Anemia, a mutation in the beta-globin chain causes hemoglobin S to polymerize when oxygen levels are low. This polymerization deforms the erythrocyte into a rigid, sickle-like shape that can obstruct small blood vessels.
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