What is the primary role of the polyadenylation signal (AAUAAA) in eukaryotic transcripts?
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Correct answer: It directs cleavage and addition of the poly-A tail
The AAUAAA polyadenylation signal is recognized by cleavage and polyadenylation specificity factor (CPSF), which cleaves the transcript 10-30 nucleotides downstream. Poly-A Polymerase then adds ~200 adenine residues to the 3' end, stabilizing the mRNA.
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