Cytoskeleton and Its Filaments · Zoology

Which of the following describes the polarity of a microtubule?

  1. The plus end exposes alpha-tubulin; the minus end exposes beta-tubulin
  2. The plus end exposes beta-tubulin; the minus end exposes alpha-tubulin
  3. Microtubules are non-polar, unlike actin filaments
  4. Polarity is established by the direction of GTP hydrolysis along the lattice
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Correct answer: The plus end exposes beta-tubulin; the minus end exposes alpha-tubulin

Microtubules are structurally polar. The faster-growing plus end exposes beta-tubulin subunits, while the slower-growing (or anchored) minus end exposes alpha-tubulin. This polarity dictates the direction of motor protein movement: kinesins move toward the plus end and dyneins toward the minus end.

Difficulty: Medium Question 18 of 20

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