Cell Cycle: Phases and Checkpoints · Zoology

What triggers the transition from metaphase to anaphase?

  1. Cyclin D degradation
  2. Activation of spindle assembly checkpoint
  3. Degradation of securin
  4. DNA replication completion
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Correct answer: Degradation of securin

Degradation of securin releases separase, which cleaves cohesin proteins. This allows sister chromatids to separate during anaphase.

Difficulty: Medium Question 18 of 20

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