Renal Filtration and Electrolyte Balance · USMLE Step 1

Which hormone increases sodium reabsorption and potassium secretion in the distal nephron, thereby affecting electrolyte and volume balance?

  1. Antidiuretic hormone (ADH)
  2. Aldosterone
  3. Atrial natriuretic peptide (ANP)
  4. Parathyroid hormone (PTH)
Show answer and explanation

Correct answer: Aldosterone

Aldosterone acts on distal tubule and collecting duct principal cells, upregulating Na⁺/K⁺-ATPase and ENaC channels, increasing sodium and water reabsorption and promoting potassium secretion.

Difficulty: Medium Question 6 of 20

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