Renal Filtration and Electrolyte Balance · USMLE Step 1

Which of the following is a major mechanism by which the kidneys regulate extracellular fluid volume and blood pressure via sodium handling?

  1. Changing the glomerular filtration barrier permeability
  2. Altering glomerular capillary oncotic pressure
  3. Hormonal modulation of sodium and water reabsorption
  4. Adjusting afferent arteriole diameter only
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Correct answer: Hormonal modulation of sodium and water reabsorption

The kidneys regulate ECF volume and blood pressure by adjusting sodium (and thus water) reabsorption in response to hormones (e.g., aldosterone, ADH, RAAS), thereby modulating volume and osmolarity.

Difficulty: Medium Question 11 of 20

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